Combine the ground beef, BBQ sauce, salt, garlic powder and pepper in a medium-sized bowl. Mix just until combined with your hands and shape into 4 patties about 3/4-inch thick. Make a well in your patties with your thumb to prevent from bulging.
Place burgers on the grill and cook 4 to 5 minutes. Flip and then cook an additional 4-5 minutes, or until juices run clear. Top with cheese slices, if desired. Grill until cheese has melted and turn off the heat.
Serve hamburgers on buns with your favorite toppings.